Scientific Articles

Parkinson’s disease is the second most common neurodegenerative disease

Parkinson’s disease is the second most common neurodegenerative disease, and its prevalence has been projected to double over the next 30 years.

These sobering statistics and the quest for PD prognostic marker discovery inspired a team of scientists led by Prof. Hideaki Matsui to build upon previous knowledge that link mitochondrial dysfunction and lysosomal dysfunction to PD. In an interview Prof. Matsui said, “Our results showed for the first time that cytosolic dsDNA of mitochondrial origin leaking and escaping from lysosomal degradation can induce cytotoxicity both in cultured cells, as well as in zebrafish models of Parkinson’s disease.”

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سیاوش خلبانی

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